Table 5
Evaluation of the sensitivity of cell and medium accumulation to detect changes in biliary excretion of TS using data from Monte Carlo simulations

Monte Carlo simulations were performed by modulating the rate constant for biliary excretion of TS by three different scenarios (experimentally determined parameter estimates; 2-fold increase; 2-fold decrease). The relative power to detect a statistically significant difference in medium vs. cell was calculated as the ratio of the number of observations (*N* = sample size) necessary to detect a statistically significant difference in TS accumulation in medium to the number of observations necessary for accumulation in hepatocytes.